Search on: PROCOLLAGEN N ENDOPEPTIDASE 
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Descriptor English:   Procollagen N-Endopeptidase 
Descriptor Spanish:   Procolágeno N-Endopeptidasa 
Descriptor Portuguese:   Pró-Colágeno N-Endopeptidase 
Synonyms English:   Procollagen N-Proteinase
Procollagen N Endopeptidase
Procollagen N Proteinase
Procollagen Peptidase  
Tree Number:   D08.811.277.656.300.480.664
D08.811.277.656.675.374.664
Definition English:   An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14. 
History Note English:   97; was PROCOLLAGEN PEPTIDASE 1977-96 (see under ENDOPEPTIDASES 1977-90) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   11784 
Unique Identifier:   D011348 

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